Well this is the first time I am hearing about the comparison between Dr. House and Sherlock Holmes, but it does make a lot of sense that the character of House is based on Holmes, take a look at the comparison:

HOUSE
Name: House
Compatriot: Dr. Wilson
Drug of Choice: Vicodin, Morphine
Job: Solve Mysterious Cases (Medical)
Home: 221B, Shares Apartment with Dr. Wilson in Season 2
Skill: Incredible Deductive Powers
Nemesis: Jack Moriarty
Character: Arrogant S.O.B.
One True Love: Stacy Warner
Instrument of Choice: Piano for Contemplation
Pastime: Watches Soaps
Outside Help: Relies on Staff to Do the Dirty Biz
Significant Props: Walks with Cane
Miscellaneous: Has Wounded Leg

HOLMES
Name: Holmes
Compatriot: Dr. Watson
Drug of Choice: Cocaine, Morphine
Job: Solve Mysterious Cases (Criminal)
Home: 221B Baker Street, Shares Apartment with Dr. Watson
Skill: Incredible Deductive Powers
Nemesis: Moriarty
Character: Arrogant S.O.B.
One True Love: Irene Adler
Instrument of Choice: Violin for Contemplation
Pastime: Reads the Agony Column in Newspaper
Outside Help: Relies on Baker Street Irregulars to Do the Dirty Biz
Significant Props: Walks with Cane, Smokes Pipe
Miscellaneous: Watson Has Wounded Leg

Now all we have to do is wait to see Dr. House wear that ridiculous detective hat and the comparison will be completed~ hehe

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